Monday, February 6, 2012

Other interesting presentations from the GU Oncology meeting: Part ...

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The following is promised commentary on a second group of the more interesting?presentations last Thursday at the Genitourinary Cancer Symposium in San Francisco, with links to the more detailed abstracts. The majority of these presentations were posters as opposed to oral presentations.

  • Lin et al. presented data suggesting that, for men initially placed on active surveillance,?PCA3 and TMRPSS2-ERG levels?may be helpful in the?assessment of?risk for aggressive forms of prostate cancer (as defined by tumor volume or Gleason score) and may also have clinical utility in the selection of?men?who are appropriate candidates?for active surveillance.
  • Orsted et al. offered additional?insights from a large Danish database on the association between baseline PSA levels and 10-year risk for prostate cancer.
  • Parker et al. gave a detailed report on the results of the randomized, muticenter, Phase III clinical trial of radium-223 choride (Alpharadin?) in the treatment of men with metastatic, castration-resistant prostate cancer.
  • Hussain et al. provided initial data from a randomized Phase II trial of cixutumumab or ramucirumab (two monoclonal antibodies) plus mitoxantrone and prednisone in men with mCRPC who had progressive disease on docetaxel-based chemotherapy.
  • Small et al. demonstrated that a significant subset of men diagnosed with metastatic prostate cancer still receives no effective treatment, and that such patients tend to be disadvantaged in some way be race, income, and/or educational status.
  • Karzai et al. reported on a Phase I trial of an antibody to CD105 (endoglin) and showed that some patients with progressive mCRPC appear to respond to treatment with this antibody.
  • Similarly, Chi et al. reported data from a randomized, Phase II trial of OGX-427 suggesting that some men with progressive CRPC seem to respond to treatment with OGX-427 plus prednisone.
  • Aizer et al. reported on recent frequency of management of men with low-risk prostate cancer using active surveillance at the multi-disciplinary prostate cancer clinics of three, associated teaching hospitals in Boston, MA.
  • Trock et al. offered data on the impact of factors such as diet, supplements, and lifestyle on risk of disease progression in a current, contemporary seriescohort of patients managed with active surveillance.
  • An interesting poster by Hattangadi et al. indicates the continued importance of the digital rectal examionation (DRE) in identification of men with high-risk but localized and potentially curable?prostate cancer who have an occult (i.e., non-suspicious) PSA level.
  • Ansari et al. reported data on the outcomes of 105 men diagnosed with low- and intermediate-risk prostate cancer and managed with active surveillance at two institutions in Scotland.

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Source: http://prostatecancerinfolink.net/2012/02/05/other-interesting-presentations-from-the-gu-oncology-meeting-part-ii/

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Olympus OM-D E-M5 shots orchestrally maneuvers out of the darkness

Would you look at that? According to PhotoRumors, that chunk of retro beauty is purportedly a full-on snap of Olympus' new OM-D Micro Four Thirds shooter (from an Amazon Japan listing that's since been pulled) affixed with its optional battery grip (adding what appears to be a secondary shutter button). That, or someone knows exactly what makes us go "Oooh." The chunky '70s stylings make us fear we'd abandon our career to go become a war photographer if one of those was placed in our hands. 43Rumors believes the unit will hold a 16.1 megapixel EDR CMOS, beefier than the 12.3 sensor inside the PEN E-PL3, but we hope this new body (however beautiful it is) doesn't spell the end for the dinky PEN series. If that wasn't enough, a that Amazon listing we mentioned also pointed out a 1.44-megapixel electronic viewfinder, a tiltable OLED display on back and a total weight of 454 grams with its kit lens attached. We've got a few more shots in the gallery below, with others rocking some serious cropping, but each is more deliciously teasing than the last.

Continue reading Olympus OM-D E-M5 shots orchestrally maneuvers out of the darkness

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Source: http://www.engadget.com/2012/02/05/olympus-om-d-e-m5-shots-orchestrally-maneuvering-out-of-the-dark/

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Carnival cruise ship passengers struck with virus (Reuters)

(Reuters) ? More than 100 people on board a cruise ship operated by a unit of Carnival Corp have fallen ill with a stomach virus, the latest setback facing the world's biggest cruise company, which came under scrutiny last month for the Costa Concordia cruise ship disaster in Italy.

Ninety passengers and 13 crew members on the Ruby Princess cruise ship contracted the Norovirus, a contagious gastrointestinal illness that causes vomiting and diarrhea for one to three days, Julie Benson, a spokeswoman for Princess Cruises, a unit of Carnival, said in a statement.

The Ruby Princess set sail from Fort Lauderdale, Florida, on January 29 to the Caribbean and returned to Florida on Sunday, as scheduled. Another Carnival ship, the Crown Princess, was affected by the same virus last week, but it has been sanitized and has already embarked on its next cruise, Benson said.

Carnival is dealing with the financial impact of the Costa Concordia shipwreck, which tarnished its image and raised questions about the safety of the entire luxury cruise ship industry. The Costa Concordia capsized off the coast of Italy, killing 17 people. Fifteen people are still missing.

Carnival said on January 30 it would take a profit hit ranging from $155 million to $175 million this year because of costs related to the wreck. The company has said it will release a revised full-year earnings forecast in March.

Royal Caribbean Cruise Ltd, the second-largest cruise operator and one of Carnival's rivals, warned on February 2 that it would face a sharp drop-off in new cruise bookings because of the wreck, which could cut its earnings in half during the current quarter.

Shares of Carnival closed at $32.00 per share on the New York Stock Exchange on Friday while shares of Royal Caribbean closed at $30.59.

(Reporting By Liana B. Baker; Editing by Leslie Adler)

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20120205/wl_nm/us_carnival

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Sunday, February 5, 2012

After UN veto, US floats coalition on Syria (AP)

BEIRUT ? The United States proposed an international coalition to support Syria's opposition Sunday after Russia and China blocked a U.N. attempt to end nearly 11 months of bloodshed, raising fears that violence will escalate. Rebel soldiers said force was now the only way to oust President Bashar Assad, while the regime vowed to press its military crackdown.

The threat of both sides turning to greater force after Russia and China vetoed a U.N. Security Council resolution raises the potential for Syria's turmoil to move into even a more dangerous new phase that could degenerate into outright civil war.

The uprising inspired by other Arab Spring revolts began in March with peaceful protests against Assad's regime, sparking a fierce crackdown by government forces. Soldiers who defected to join the uprising later began to protect protesters from attacks. In recent months, the rebel soldiers, known as the Free Syrian Army, have grown bolder, attacking regime troops and trying to establish control in pro-opposition areas. That has brought a heavier government response.

More than 5,400 people have been killed since March, according to the U.N., and now regime opponents fear that Assad will be emboldened by the feeling he is protected by his top ally Moscow and unleash even greater violence to crush protesters. If the opposition turns overtly to armed resistance, the result could be a dramatic increase in bloodshed.

At least 30 civilians were killed Sunday, including five children and a woman who was hit by a bullet while standing on her balcony as troops fired on protesters in a Damascus suburb, according to the Britain-based Syrian Observatory for Human Rights, an activist group.

Government forces firing mortars and heavy machine guns also battered the mountain town of Zabadani, north of Damascus, a significant opposition stronghold that fell under rebel control late last month. Bombardment the past two days has wounded dozens and forced scores of families to flee, an activist in the town said.

"The situation is terrifying. Makeshift hospitals are full," said the activist, who only gave his first name, Fares, for fear of government reprisal. He said the town has been under siege for the past five days and there is a shortage of food and heating fuel during the cold winter.

The commander of the Free Syrian Army told The Associated Press that, after the vetoes at the U.N., "there is no other road" except military action to topple Assad.

"We consider that Syria is occupied by a criminal gang and we must liberate the country from this gang," Col. Riad al-Asaad said, speaking by telephone from Turkey. "This regime does not understand the language of politics. It only understands the language of force."

U.S. Secretary of State Hillary Rodham Clinton warned that chances for "a brutal civil war" would increase as Syrians under attack from their government move to defend themselves, unless international steps provide another way.

Speaking to reporters in the Bulgarian capital of Sofia, she called the double veto at the U.N. Security Council on Saturday "a travesty."

"Faced with a neutered Security Council, we have to redouble our efforts outside of the United Nations," she said, calling for "friends of democratic Syria" to unite "support the Syrian people's right to have a better future."

The call points to the formation of a formal group of like-minded nations to coordinate assistance to the Syrian opposition, similar but not identical to the Contact Group on Libya, which oversaw international help for opponents of the late deposed Libyan leader Moammar Gadhafi. In the case of Libya, the group also coordinated NATO military operations to protect Libyan civilians, something that is not envisioned in Syria.

U.S. officials said an alliance would work to further squeeze the Assad regime by stepping up sanctions against it, bringing disparate Syrian opposition groups inside and outside the country together, providing humanitarian relief for embattled Syrian communities and working to prevent an escalation of violence by monitoring arms sales.

The main Syrian opposition umbrella group, the Syrian National Council, backed the idea.

Radwan Ziadeh, a prominent figure in the SNC, wrote on his Facebook page that friendly countries should form an "international coalition ... whose aim will be to lead international moves to support the revolution through political and economic aid."

A deeply sensitive question is whether such a coalition would back the Free Syrian Army. There appears to be deep hesitation among Western countries, fearing further militarization of the conflict.

Omar Idlibi, an activist with the Syrian National Council, said action by a "friends coalition" to increase sanctions and other steps would boost peaceful opposition through protests.

But, he said, it should also include support to the FSA, which he said would prevent civilians from taking up arms, worsening the conflict.

The FSA, he said, "is a national Syrian army and as the regime has the right to get help from its Russian and Iranian allies, it is the right of the opposition to ask for help from its friends in enabling the Syrian people to achieve change."

The FSA, based in neighboring Turkey, is believed to number several thousand soldiers and it almost daily announces claims of groups of soldiers joining its ranks that cannot be confirmed. It is heavily outgunned by the powerful regime military, which still has the power to conduct focused operations that can drive the rebels out of any areas they gain control of.

But the military cannot cover everywhere at once, and FSA troops appear to be proving effective at hit-and-run attacks and have put up staunch resistance in assaults on opposition-dominated urban areas.

On Sunday, rebel soldiers attacked a military convoy in the northwestern province of Idlib, killing 14 government troops, the Observatory said, reporting that 14 other regime soldiers were killed in fighting elsewhere.

Early Saturday, regime forces bombarded the restive central city of Homs, apparently in response to FSA attacks. Activists said the bombardment was the deadliest incident of the uprising, killing more than 200 people in a single day. The regime denied any bombardment, and there was no way to independently confirm the toll.

Gunfire continued to ring out Sunday in several neighborhoods of Homs, and at least 23 people were killed in the city and nearby towns, including three children, the Observatory said. Grisly video posted by activists online showed a young boy said to have been wounded in the shooting, his jaw torn away. The video and the Observatory's casualty reports could not be independently confirmed.

The Russian and Chinese vetoes effectively killed an Arab League plan that called for Assad to hand over power to his vice president and allow the creation of a unity government. The resolution would have expressed support for the Arab League plan, which Assad rejected.

The Syrian government touted the U.N. result as a victory.

The state-run newspaper, Tishreen, vowed that Damascus will press its crackdown aiming to restore "stability and security and confront all forms of terrorism." The regime has portrayed the uprising as the work of terrorists and armed gangs as part of a foreign conspiracy.

Hundreds of regime supporters rallied in a Damascus square, waving Russian and Chinese flags in gratitude for blocking the resolution.

"Thanks Russia, thanks China for undermining the Western conspiracy against our country," said Nibal Hmeid, a 24-year-old teacher at the rally. She said Assad should now settle the situation "decisively and militarily against those armed criminals."

____

AP correspondent Matthew Lee reported from Sofia, Bulgaria. AP correspondent Bassem Mroue in Beirut contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/un/*http%3A//news.yahoo.com/s/ap/20120205/ap_on_re_mi_ea/ml_syria

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India's Congress wins court reprieve over telecoms scandal (Reuters)

NEW DELHI (Reuters) ? India's beleaguered government won some rare relief on Saturday when a court threw out a corruption case against one its top ministers ahead of crucial state elections next week.

The court dismissed a petition accusing Home Minister Palaniappan Chidambaram of signing off on the sale of telecoms licenses at below-market prices that may have cost the government up to $36 billion in lost revenues.

Prime Minister Manmohan Singh's Congress party, struggling against repeated accusations of graft and incompetence, faces elections starting next week in a key northern state that was once its stronghold and whose voters could set the tone for 2014 national polls.

The latest ruling can still be challenged in a higher court.

The accusations against Chidambaram relate to his position as finance minister in 2008 at the time of the corruption-tainted telecoms bidding.

It is the biggest of several scandals to have emerged during

Singh's second term, denting India's image as an investment destination and heightening concerns over policy when Asia's third largest economy is slowing.

The Supreme Court on Thursday ordered 122 telecoms licenses issued under that 2008 sale be revoked.

Two ministers, including former telecoms minister Andimuthu Raja who presided over the 2008 grant process, have resigned. Raja is in jail awaiting trial.

Saturday's court ruling also removes one major political weapon from the opposition which has been unrelenting in its attacks on the government over corruption. For most of last year, opposition parties have repeatedly blocked policy going through parliament.

A major next test will be the 2012\13 budget for which the government is hoping to get parliamentary approval in mid-March.

(Reporting by Suchitra Mohanty, Writing by Krittivas Mukherjee, Editing by Jonathan Thatcher)

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/nm/20120204/wl_nm/us_india_corruption_court

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Maintained Catastrophe Gears ? All About Everything

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Endurance guide has to be incorporated as a part of every kit. It has to involve some lists of every survival gear inside of a sorted style and must clarify anybody attributes in merely comprehendible language. It will be very helpful and necessary during emergencies, due to the fact comprehending furnished with a few tactics could possibly be the difference between life and death. So, someone ought to make sure that they?ve by now an intensive yet swiftly clear to see courses that aren?t only informative but will also acts as the reference specify your survivors.

Persons has got to take tend to have a far better survival guide or make one on their own. Apart from delivering info about the contents, the survival guide also need to offer you guidance in connection with the places of using of you surviving gear, the shelf lives in the contents, coupled with their usage moment.

This post seen on this page is usually very critical for the many disaster preparation we start to use. A proper supposed and prepared survival supplies and guide may help survivors of difficulties to maintain themselves much more time.

Learn more about survival supplies. Stop by dansdepot.com site where you can find out all about survival gear and what it can do for you.

Source: http://allbout.info/maintained-catastrophe-gears/

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Saturday, February 4, 2012

Def Sec'y Panetta: Pressure must be kept on Iran

Lt. Gen. Stephen P. Mueller welcomes Defense Secretary Leon Panetta to Ramstein Air Base, Germany, Friday, Feb. 3, 2012. (AP Photo/Jacquelyn Martin, Pool)

Lt. Gen. Stephen P. Mueller welcomes Defense Secretary Leon Panetta to Ramstein Air Base, Germany, Friday, Feb. 3, 2012. (AP Photo/Jacquelyn Martin, Pool)

Defense Secretary Leon Panetta speaks to service members at Ramstein Air Base, Germany, Friday, Feb. 3, 2012. (AP Photo/Jacquelyn Martin, Pool)

Defense Secretary Leon Panetta shakes hands with service members, including Airman 1st Class Alexis McGarrity, of Plattsburgh, N.Y., Friday, Feb. 3, 2012, at Ramstein Air Base, Germany. (AP Photo/Jacquelyn Martin, Pool)

(AP) ? U.S. Defense Secretary Leon Panetta said Friday the key to stopping Iran from getting a nuclear bomb is keeping global support for tough economic sanctions.

Speaking to US airmen in Germany, Panetta reiterated that if Iran does not change course, the US is "prepared to respond if we have to."

Panetta was responding to an airman who asked at what point the United States would get involved in Israel's potential conflict with Iran. Panetta sidestepped that aspect of the Iran issue and focused on international efforts to persuade Iran to not build the bomb.

He reiterated that all U.S. options are on the table, implying the possibility of using military force.

"My view is that right now the most important thing is to keep the international community unified," Panetta said, "so we're keeping that pressure on to convince Iran that they shouldn't develop a nuclear weapon, that they should join the international family of nations" and abide by international norms.

"If they don't, we have all options on the table and would be prepared to respond if we have to," he said.

U.S. Defense Secretary Leon Panetta won't dispute a report that he believes Israel may attack Iran this spring in an attempt to set back the Islamic republic's nuclear program.

On Thursday, Panetta was asked by reporters to comment on a Washington Post opinion column by David Ignatius that said the secretary believes there is?a "strong likelihood" that Israel will attack Iran in April, May or June. Ignatius did not?say who told him this.

Asked whether he disputes the report, Panetta said, "No, I'm just not commenting."

He added, "What I think and what I view, I consider that to be an area that belongs to me and nobody else."

Panetta noted that Israel has stated publicly that it is considering military action against Iran. He said the U.S. has "indicated our concerns."

Panetta was at Ramstein Air Base Friday to visit troops after attending NATO meetings in Brussels. Later Friday, he was heading to Munich to attend an international security conference Saturday where Iran was certain to be among the topics discussed.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-02-03-EU-Panetta-Iran/id-58804d578bd9498cb7630768b264133a

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